Ethylphenidate or EP is a very popular research chemical which binds to and blocks the protein transporter responsible for the re-uptake of Dopamine and Norepinephrine. Ethylphenidate is structurally similar to Methylphenidate. Although, having the same efficacy, in vitro (outside living organism) as Methylphenidate, EP has a higher affinity for the Dopamine transporter protein. EP has a lower affinity, however, for the Norepinephrine transporter protein.
What is Ethylphenidate used for?
Being a ligand for the Transporter proteins for both norepinephrine and dopamine, Ethylphenidate would be useful as an analytical agent for profiling these transporter proteins, in vitro. Researchers could apply solutions containing Ethylphenidate to a membrane infused with dopamine or norepinephrine protein transporters and measure the efficacy it has upon them. Affinity profiles for Ethylphenidate for these two transporter proteins could be analysed in the same way as the above, however, by performing a competitive binding assay with an appropriate chemical. All of the above should be performed in vitro.
Ethylphenidate may be used as a primary reagent for chemistry experiments. It may also be used as a chemical reference for forensics or toxicologists for GC/MS, NMR, FTIR or HPLC analysis libraries.
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